Thomas P Loughran Selected Research

Large Granular Lymphocytic Leukemia

1/2022	miR-181a is a novel player in the STAT3-mediated survival network of TCRαβ+ CD8+ T large granular lymphocyte leukemia.
1/2022	Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia.
1/2022	Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis.
1/2020	Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations.
1/2019	Retrovirus insertion site analysis of LGL leukemia patient genomes.
1/2019	IL-2 and IL-15 blockade by BNZ-1, an inhibitor of selective γ-chain cytokines, decreases leukemic T-cell viability.
11/2018	Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes.
1/2018	Somatic STAT3 mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.
1/2018	TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia.
1/2018	Calcitriol-mediated reduction in IFN-γ output in T cell large granular lymphocytic leukemia requires vitamin D receptor upregulation.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Thomas P Loughran Research Topics

Disease

48	Large Granular Lymphocytic Leukemia 01/2022 - 12/2002
41	Neoplasms (Cancer) 01/2022 - 08/2003
21	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 08/2003
19	Leukemia 01/2022 - 08/2003
6	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 03/2002
5	Autoimmune Diseases (Autoimmune Disease) 01/2018 - 08/2002
4	Infections 01/2020 - 04/2003
4	Cytopenia 10/2013 - 08/2003
3	Disease Progression 09/2021 - 08/2003
3	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2018 - 12/2002
3	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2016 - 08/2003
3	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 05/2012 - 05/2010
3	Neutropenia 03/2011 - 01/2004
2	Carcinogenesis 01/2022 - 01/2012
2	Multiple Myeloma 01/2020 - 01/2010
2	Felty Syndrome (Syndrome, Felty's) 01/2018 - 09/2006
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2017 - 01/2013
2	Genetic Translocation (Chromosomal Translocation) 01/2017 - 12/2002
2	T-Cell Prolymphocytic Leukemia (Leukemia, T Cell, Chronic) 03/2016 - 06/2015
2	Breast Neoplasms (Breast Cancer) 01/2016 - 07/2011
2	Hemorrhage 03/2015 - 01/2002
2	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 11/2014
2	Anemia 09/2012 - 03/2011
2	T-Cell Leukemia (Leukemia, T Cell) 05/2012 - 04/2003
1	Thrombocytopenia (Thrombopenia) 01/2021
1	Leukemic Infiltration 01/2020
1	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 01/2019
1	Rheumatoid Arthritis 01/2018
1	Extranodal NK-T-Cell Lymphoma 01/2018

Drug/Important Bio-Agent (IBA)

19	SphingolipidsIBA 01/2022 - 08/2008
16	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2003
13	CytokinesIBA 01/2020 - 02/2003
13	CeramidesIBA 01/2020 - 11/2010
11	Pharmaceutical PreparationsIBA 01/2020 - 01/2004
10	AntigensIBA 01/2022 - 07/2003
6	Interleukin-15 (Interleukin 15)IBA 01/2019 - 05/2009
5	N-caproylsphingosineIBA 01/2017 - 01/2013
5	Methotrexate (Mexate)FDA LinkGeneric 07/2012 - 08/2003
5	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/2012 - 08/2003
4	Tamoxifen FDA LinkGeneric 01/2019 - 07/2015
4	Calcitriol (Calcijex)FDA LinkGeneric 11/2018 - 01/2017
4	sphingosine kinaseIBA 07/2017 - 10/2008
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 05/2008 - 08/2003
3	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2020 - 05/2012
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 05/2010
3	Acid CeramidaseIBA 01/2019 - 07/2015
3	N'- ((1E)- 1- (3,4- dimethoxyphenyl)ethylidene)- 3- (4- methoxyphenyl)- 1H- pyrazole- 5- carbohydrazideIBA 07/2017 - 01/2015
3	Farnesyltranstransferase (Farnesyltransferase)IBA 04/2012 - 12/2008
2	Transcription Factors (Transcription Factor)IBA 01/2022 - 04/2012
2	T-Cell Antigen Receptors (T-Cell Receptor)IBA 01/2022 - 10/2005
2	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 03/2013
2	ChemokinesIBA 01/2022 - 02/2005
2	AntibodiesIBA 01/2019 - 01/2012
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 01/2019 - 01/2017
2	Interleukin-2 (IL2)IBA 01/2019 - 04/2003
2	Cytarabine (Cytosar-U)FDA LinkGeneric 01/2019 - 04/2016
2	Tyrosine (L-Tyrosine)FDA Link 11/2018 - 01/2018
2	Interferon-gamma (Interferon, gamma)IBA 01/2018 - 04/2003
2	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2018 - 03/2017
2	Proteasome InhibitorsIBA 01/2018 - 05/2009
2	EnzymesIBA 06/2017 - 07/2015
2	CalciumIBA 03/2017 - 07/2011
2	Vitamin D FDA LinkGeneric 03/2017 - 01/2017
2	Adenosine Triphosphate (ATP)IBA 01/2016 - 01/2013
2	Cadherins (E-Cadherin)IBA 01/2015 - 11/2014
2	marinopyrrole AIBA 08/2014 - 03/2012
2	Peptides (Polypeptides)IBA 05/2012 - 04/2005
2	EpitopesIBA 05/2012 - 04/2005
2	Interleukin-12 (IL 12)IBA 04/2012 - 02/2005
2	tipifarnib (R115777)IBA 04/2012 - 05/2010
2	Sphingosine-1-Phosphate ReceptorsIBA 11/2011 - 12/2002
2	Fingolimod Hydrochloride (FTY720)FDA Link 09/2011 - 08/2008
2	Neutralizing AntibodiesIBA 04/2011 - 01/2010
2	GlucocorticoidsIBA 05/2008 - 09/2006
2	Amino Acids FDA Link 04/2005 - 11/2003
2	RNA (Ribonucleic Acid)IBA 02/2005 - 05/2003
2	Fas Ligand Protein (Fas Ligand)IBA 02/2005 - 08/2002
1	AutoantibodiesIBA 01/2022
1	MicroRNAs (MicroRNA)IBA 01/2022
1	Electron Transport Complex I (NADH-CoQ Reductase)IBA 01/2022
1	HLA-DR4 Antigen (HLA DR4 Antigen)IBA 01/2022
1	LuciferasesIBA 09/2021
1	Protein Kinases (Protein Kinase)IBA 09/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021
1	IsatinIBA 01/2020
1	Aldehyde DehydrogenaseIBA 01/2020
1	Agammaglobulinaemia Tyrosine KinaseIBA 01/2020
1	Estrogen Receptor Modulators (Antiestrogen)IBA 01/2019
1	Daunorubicin (Cerubidine)FDA LinkGeneric 01/2019
1	Messenger RNA (mRNA)IBA 01/2018
1	Bortezomib (Velcade)FDA Link 01/2018
1	LigandsIBA 01/2018
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2018
1	ixazomibIBA 01/2018
1	TNF-Related Apoptosis-Inducing LigandIBA 01/2018
1	TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA 01/2018
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2018

Therapy/Procedure

24	Therapeutics 01/2019 - 08/2003
5	Drug Therapy (Chemotherapy) 01/2022 - 07/2003
2	Immunotherapy 03/2016 - 03/2002